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all the information, none of the junk | biotech • healthcare • life sciences amag pharmaceuticals reaches 3-year milestone amag pharmaceuticals, a biopharmaceutical company focused on lipid-lowering drugs, has announced that the bioavailability of its anacetrapib product (sygemon) has been met in a pilot study that evaluated the 3-year safety and efficacy of the drug. the company launched the product in 2007, after completing a phase 2 clinical trial, known as the apollo-timi clinical program. results from the 1-year, follow-up of this trial suggested that amag’s anacetrapib product lowered the levels of certain atherogenic cholesterol markers in the blood of patients. the goal of the apollo-timi trial was to evaluate the long-term safety and efficacy of anacetrapib in more patients with high cholesterol. patients in the trial were considered to have high cholesterol if their low-density lipoprotein (ldl) cholesterol was 150 milligrams per deciliter or higher, or if their total cholesterol was 200 milligrams per deciliter or higher, and triglyceride levels were 110 milligrams per deciliter or higher. convenience and pregnancy study the amag-sponsored apollo-timi trial included more than 1,700 patients from 110 centers worldwide. the study’s conclusions will be based on measures of lipid and blood chemistry taken after 12 months of treatment with anacetrapib, as well as the incidence of adverse events and pregnancy complications. analysis of the metabolic parameters showed that the patients in the study’s anacetrapib group had a decrease in ldl cholesterol of 32 percent after 12 months of treatment compared to a decrease of only 3 percent in the placebo group. the difference was statistically significant, according to amag. safety and tolerability of the drug was also assessed by participants in the study. adverse events were recorded in over 99 percent of the anacetrapib patients and in over 98 percent of the placebo patients. the most common adverse reactions in the anacetrapib group were cough and wheezing. the company said one patient in the anacetrapib group was diagnosed with a “liver-related event” after one year of treatment. two participants in the anacetrapib group also experienced a condition known as “hypersensitivity-related cough,” according to amag, which said that all such side effects are rare and have occurred in less than 1 percent of patients with high cholesterol.filter by: related products gopro hero5 black hd action camera with led light and grip capture your adventures in breathtaking action. the gopro hero5 black with advanced warfighter lens features the most powerful video and photo resolution ever, as well as built-in wi-fi and a new lcd screen that’s easy to view in daylight or… gopro hero5 black hd action camera with advanced warfighter lens capture your adventures in breathtaking action. the gopro hero5 black with advanced warfighter lens features the most powerful video and photo resolution ever, as well as built-in wi-fi and a new lcd screen that’s easy to view in daylight or at night. it uses the same robust, easy-to-use waterproof housing as the original gopro hero camera, but adds a curved screen, better image stabilization, and a built-in microphone, which makes it perfect for all kinds of high-quality, immersive recording.
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