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Pancreatic adenocarcinoma is the most common form of pancreatic cancer. The risk factors associated with this disease are age, sex, race, smoking, family history and genetic factors. Treatment for pancreatic adenocarcinoma involves a combination of surgery, radiation and chemotherapy. Surgical resection of the tumor is no longer considered the best option, as the tumor is almost always inoperable by the time of diagnosis, and the 5-year survival rate after surgery is only 3-5 percent.
Pancreatic cancer is more likely to spread to distant organs than other cancers and therefore is more difficult to treat. The most common site of metastasis of pancreatic cancer is the liver, followed by the lung, the adrenal gland and the peritoneum. The most common symptom of advanced pancreatic cancer is the obstruction of the common bile duct and/or the distal common bile duct. Other symptoms may include weight loss, abdominal pain, vomiting, jaundice and problems with eating or urinating.
Chemotherapy is the treatment of choice for most pancreatic adenocarcinoma. Chemotherapeutic agents used include 5-fluorouracil, cisplatin, doxorubicin and gemcitabine. While some of these drugs have shown promise, pancreatic cancer remains incurable.
Currently, pancreatic cancer can only be diagnosed by a needle biopsy in a procedure that involves cutting out a small piece of tissue from the body. Because of the small size of the tumor, this procedure often fails to provide any information about the staging and/or differentiation of the cancer. However, such information is very important to determining whether the cancer has metastasized or whether it is treatable. Until recently, there has been no effective method of detecting pancreatic cancer