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There are many interneurons in the brain. It is estimated that the human brain contains as many as 80 billion neurons and an equal number of glia cells. The composition of each cell type and their location in the brain, makes them highly vulnerable and “fragile” to degeneration, suggesting that the loss of these cells, a hallmark of Alzheimer’s disease (AD), has far-reaching, detrimental consequences for the brain. As a neurodegenerative disorder that affects cognitive functioning, it is important to understand how synaptic dysfunctions and the progression of the disease cause pathological manifestations in the brain. Recent studies demonstrated that intracellular signaling molecules and their pathways are required for the normal homeostasis of AD interneurons. In this study, we review the mechanisms that regulate the normal function of these cells, and review the results of various pathophysiological studies that target this neuronal subset. A better understanding of the molecular mechanisms by which different proteins function together to maintain interneuron integrity, and how they become faulty, will likely lead to novel, targeted drug therapies for AD and other neurodegenerative diseases.Q:
Access Json and set value based on Condition
I am reading JSON data from a URL, and this is how it looks like:
{
“2365”: {
“ID”: “2365”,
“user_ID”: “12034”,
“name”: “BGP”,
“parent_ID”: “2222”,
“group_ID”: “0”,
“group_name”: “”,
“created_at”: “2020-03-11 15:49:39”
},
“4308”: {
“ID”: “4308”,
“user_ID”: “1111”,
“name”: “IPS”,
“parent_ID”: “2222”,
“group_ID”: “0”,
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