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In recent years, the rapid progress in molecular biology has enabled clinicians to access not only genetic mutations and neoantigens, but also the proteins and metabolites. The identification of specific biomarkers allows disease diagnosis, determination of prognosis, and assessment of response to treatment. In cancer, biomarkers can be broadly divided into several categories. Molecular biomarkers such as biomarkers based on gene expression profiles, DNA mutations and genomic instability are useful to accurately diagnose cancer and identify genetic differences between cancer and normal tissues. Prognostic markers are useful to define the prognosis, in which the presence of a high level of tumor marker such as serum alpha-fetoprotein in patients with hepatocellular carcinoma or lactate dehydrogenase in patients with small-cell lung cancer predicts poor survival and treatment responsiveness. Biomarkers for imaging and monitoring are considered as biomarkers of treatment response. Considering their clinical value, current biomarkers for cancer are listed in this review.Thomas King (priest)
Thomas King (1766–1844), was an English clergyman and academic.
He was born at Weaverham, on 7 March 1766, was a son of the Rev. Thomas King, vicar of Bishops Tawton, Devon. He was educated at Exeter College, Oxford, matriculating on 3 January 1785, and obtaining a second class in arts in 1788, and in divinity in 1789. He was bachelor of arts in 1791, and took orders on 2 April 1792.
He held the benefice of Tawton from 1792 until 1821, when he resigned, was perpetual curate there, and vicar of Dedford, Berks., from 1821 to his death on 2 December 1844.
He was the author of An Historical and Critical Account of the Wars in the World (1841).
He died unmarried on 2
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