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Cadaveric renal transplantation with preservation in cold storage (SC) has been associated with a higher incidence of early graft rejection, attributed to the suboptimal preservation in SC. Machine perfusion (MP) could provide a better preservation option for organs destined for transplantation, due to the maintenance of organ functional parameters. A retrospective analysis was performed of 332 cadaveric renal transplants performed at the University of Barcelona (Spain). A total of 226 grafts were transplanted with immediate perfusion with the KARMAN system. The remaining 106 grafts were transplanted with SC in the LRS machine. The main outcome was the relationship between the cold ischemia time (CIT) and subsequent rejection. According to the study protocol, CIT was classified as between 24 and 26 hours in 10 cases, 26 to 30 hours in 74 cases and more than 30 hours in 132 cases. The overall 1-month graft survival was 85%. The number of patients that experienced a rejection episode and the incidence of rejection episodes were higher in the SC group than in the KARMAN group (17 cases in SC group against 13 in the MP group, p30 hours (OR 5.3, p
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