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Organophosphorus compounds (OP) are responsible for a large number of acute and chronic health problems. Their toxicological effects are related to their pharmacological properties, which result from their ability to inhibit specific metabolic enzymes and interfere with the nervous system. We present a review on the neurological effects of OP as those of the suppression of cholinesterase activity, of their non-cholinergic effects and on the structural changes observed in the central nervous system (CNS). Opioid and muscular blocking properties seem to be the most immediate action of OP. Moreover, peripheral parasympathetic block and/or central muscarinic blockade and inhibition of cholinergic and non-cholinergic transmission mediated by the central nervous system have been demonstrated. Following OP exposure, cholinergic and non-cholinergic effects are expressed through the whole neurological system at different times, as well as structural brain modifications such as cell death, neuronal loss, neuronal plasticity and behavioral modifications. Finally, in this article, we study some of the mechanisms involved in the chronic effects of OP, and their consequences for the welfare of workers exposed to these toxicants. for which an assignee could sue in state court. See Harris v. Travelers Insurance Co., 656 F.2d 557, 562 (8th Cir.1981). But see Anderson v. American Insurance Co., 376 F.Supp. 416, 418 (W.D.Mo.1974) (insurer of dry-cleaning corporation was entitled to indemnification from employer, also insured by the insurer, although the employer had settled for full amount of damages, leaving insurer to share the loss through subrogation).
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Nationwide also argues that the excess judgment rule does not apply to the assignment of the homeowner’s underinsured motorist policy. Nationwide suggests that the Ohio Legislature must have intended that excess judgments could be collected directly from the insurer. National Union, however, dealt with a statute requiring that uninsured motorist insurance be included as part of the policy of the insured’s automobile insurance. The court’s reference to an “assignment
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