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Intestinal permeability in irritable bowel syndrome.
The aim of this work was to identify in irritable bowel syndrome (IBS) patients a subgroup which, by characterizing the permeability pattern, could better distinguish between a subgroup with the typical pattern of diarrhea predominant-IBS (IBS-D) and one presenting the constipation predominant-IBS (IBS-C) characteristic picture. One hundred and fifteen consecutive IBS patients were investigated on two separate days for intestinal permeability: substances labeled with a fluorescein (F) and radiolabeled with lactulose and mannitol (L and M), and proteins labeled with the polyethylene glycol labeled with a bicarboxylic acid (PEG-D). Transit time and absorption were calculated by deconvolution. Small bowel transit time was delayed in approximately 62% of IBS patients. The degree of intestinal permeability in IBS patients was not significantly different in L/M or in PEG-D absorption. The only parameter which was significantly different in IBS-D patients from IBS-C, was the absorption of PEG. No difference was found in L/M or in PEG-D absorption between IBS patients presenting a typical “diarrhea” pattern and those presenting a “constipation” pattern. Our results confirm the hypothesis that a subgroup of IBS patients with a “constipation” or “diarrhea” pattern has a different degree of permeability than the rest of the IBS patients. Since the L/M transit time was normal in both IBS-D and IBS-C subgroups, we do not attribute the permeability modification to any alteration in small bowel transit time.George R. Wharton Jr.
George Roeliff “Doc” Wharton Jr. (April 11, 1916 – February 21, 2005) was an American doctor, baseball player and coach. He was the head baseball coach for the Washington University in St. Louis and at the Illinois State University.
Early years
Wharton was born in St. Louis, Missouri and attended Edward S. White High School. He attended Washington University
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